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Energetic and structural basis for activation of the epithelial sodium channel by matriptase

Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying the regulation and activation of many enzymes, receptors and other proteins synthesized as inactive precursors. Serine proteases are one of the largest and conserved families of endopeptidases involved in dive...

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Detalhes bibliográficos
Main Authors: Kota, Pradeep, García-Caballero, Agustin, Dang, Hong, Gentzsch, Martina, Stutts, M. Jackson, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404201/
https://ncbi.nlm.nih.gov/pubmed/22471557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2014773
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