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Energetic and structural basis for activation of the epithelial sodium channel by matriptase

Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying the regulation and activation of many enzymes, receptors and other proteins synthesized as inactive precursors. Serine proteases are one of the largest and conserved families of endopeptidases involved in dive...

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Détails bibliographiques
Auteurs principaux: Kota, Pradeep, García-Caballero, Agustin, Dang, Hong, Gentzsch, Martina, Stutts, M. Jackson, Dokholyan, Nikolay V.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404201/
https://ncbi.nlm.nih.gov/pubmed/22471557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2014773
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