The N-terminal Domain Allosterically Regulates Cleavage and Activation of the Epithelial Sodium Channel

The epithelial sodium channel (ENaC) is activated upon endoproteolytic cleavage of specific segments in the extracellular domains of the α- and γ-subunits. Cleavage is accomplished by intracellular proteases prior to membrane insertion and by surface-expressed or extracellular soluble proteases once...

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Autors principals: Kota, Pradeep, Buchner, Ginka, Chakraborty, Hirak, Dang, Yan L., He, Hong, Garcia, Guilherme J. M., Kubelka, Jan, Gentzsch, Martina, Stutts, M. Jackson, Dokholyan, Nikolay V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4132802/
https://ncbi.nlm.nih.gov/pubmed/24973914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570952
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