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The N terminus of α-ENaC mediates ENaC cleavage and activation by furin

Epithelial Na(+) channels comprise three homologous subunits (α, β, and γ) that are regulated by alternative splicing and proteolytic cleavage. Here, we determine the basis of the reduced Na(+) current (I(Na)) that results from expression of a previously identified, naturally occurring splice varian...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Kota, Pradeep, Gentzsch, Martina, Dang, Yan L., Boucher, Richard C., Stutts, M. Jackson
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6080898/
https://ncbi.nlm.nih.gov/pubmed/29980634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711860
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