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Deubiquitylation Regulates Activation and Proteolytic Cleavage of ENaC
The epithelial sodium channel (ENaC) is critical for sodium and BP homeostasis. ENaC is regulated by Nedd4-2–mediated ubiquitylation, which leads to its internalization; this process can be reversed by deubiquitylation, which is regulated by the aldosterone-induced enzyme Usp2-45. In a second regula...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society of Nephrology
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2573013/ https://ncbi.nlm.nih.gov/pubmed/18701608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007101130 |
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