Deubiquitylation Regulates Activation and Proteolytic Cleavage of ENaC

The epithelial sodium channel (ENaC) is critical for sodium and BP homeostasis. ENaC is regulated by Nedd4-2–mediated ubiquitylation, which leads to its internalization; this process can be reversed by deubiquitylation, which is regulated by the aldosterone-induced enzyme Usp2-45. In a second regula...

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Bibliografske podrobnosti
Main Authors: Ruffieux-Daidié, Dorothée, Poirot, Olivier, Boulkroun, Sheerazed, Verrey, François, Kellenberger, Stephan, Staub, Olivier
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2008
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573013/
https://ncbi.nlm.nih.gov/pubmed/18701608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007101130
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