SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage

Many epithelia, including the superficial epithelia of the airways, are thought to secrete “volume sensors,” which regulate the volume of the mucosal lining fluid. The epithelial Na(+) channel (ENaC) is often the rate limiting factor in fluid absorption, and must be cleaved by extracellular and/or i...

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Detalhes bibliográficos
Main Authors: Garcia-Caballero, Agustin, Rasmussen, Julia E., Gaillard, Erol, Watson, Michael J., Olsen, John C., Donaldson, Scott H., Stutts, M. Jackson, Tarran, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708735/
https://ncbi.nlm.nih.gov/pubmed/19541605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903609106
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