SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage

Many epithelia, including the superficial epithelia of the airways, are thought to secrete “volume sensors,” which regulate the volume of the mucosal lining fluid. The epithelial Na(+) channel (ENaC) is often the rate limiting factor in fluid absorption, and must be cleaved by extracellular and/or i...

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Autori principali: Garcia-Caballero, Agustin, Rasmussen, Julia E., Gaillard, Erol, Watson, Michael J., Olsen, John C., Donaldson, Scott H., Stutts, M. Jackson, Tarran, Robert
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708735/
https://ncbi.nlm.nih.gov/pubmed/19541605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903609106
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