Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways

The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia. We have previously identified SPLUNC1 as an autocrine inhibitor of ENaC. We have now located the ENaC inhibitory domain of SPLUNC1 to SPLUNC1's N terminus, and a peptid...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Hobbs, Carey A., Blanchard, Maxime G., Kellenberger, Stephan, Bencharit, Sompop, Cao, Rui, Kesimer, Mehmet, Walton, William G., Redinbo, Matthew R., Stutts, M. Jackson, Tarran, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2012
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448769/
https://ncbi.nlm.nih.gov/pubmed/22798424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-207431
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados