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Cathepsin B contributes to Na(+) hyperabsorption in cystic fibrosis airway epithelial cultures

ABSTRACT: In cystic fibrosis (CF) lung disease, the absence of functional CF transmembrane conductance regulator results in Cl(−)/HCO(3)(−) hyposecretion and triggers Na(+) hyperabsorption through the epithelial Na(+) channel (ENaC), which contribute to reduced airway surface liquid (ASL) pH and vol...

詳細記述

保存先:
書誌詳細
出版年:J Physiol
主要な著者: Tan, Chong Da, Hobbs, Carey, Sameni, Mansoureh, Sloane, Bonnie F, Stutts, M Jackson, Tarran, Robert
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262337/
https://ncbi.nlm.nih.gov/pubmed/25260629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.267286
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