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Cathepsin B contributes to Na(+) hyperabsorption in cystic fibrosis airway epithelial cultures
ABSTRACT: In cystic fibrosis (CF) lung disease, the absence of functional CF transmembrane conductance regulator results in Cl(−)/HCO(3)(−) hyposecretion and triggers Na(+) hyperabsorption through the epithelial Na(+) channel (ENaC), which contribute to reduced airway surface liquid (ASL) pH and vol...
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| Publicado no: | J Physiol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262337/ https://ncbi.nlm.nih.gov/pubmed/25260629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.267286 |
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