Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures

The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is a secreted, innate defense protein and an autocrine inhibitor of ENaC that is highly expressed in airway epitheli...

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Autors principals: Hobbs, Carey A., Blanchard, Maxime G., Alijevic, Omar, Tan, Chong Da, Kellenberger, Stephan, Bencharit, Sompop, Cao, Rui, Kesimer, Mehmet, Walton, William G., Henderson, Ashley G., Redinbo, Matthew R., Stutts, M. Jackson, Tarran, Robert
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882538/
https://ncbi.nlm.nih.gov/pubmed/24124190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00103.2013
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