Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways

The epithelial sodium channel (ENaC) is responsible for Na(+) and fluid absorption across colon, kidney, and airway epithelia. We have previously identified SPLUNC1 as an autocrine inhibitor of ENaC. We have now located the ENaC inhibitory domain of SPLUNC1 to SPLUNC1's N terminus, and a peptid...

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Main Authors: Hobbs, Carey A., Blanchard, Maxime G., Kellenberger, Stephan, Bencharit, Sompop, Cao, Rui, Kesimer, Mehmet, Walton, William G., Redinbo, Matthew R., Stutts, M. Jackson, Tarran, Robert
פורמט: Artigo
שפה:Inglês
יצא לאור: Federation of American Societies for Experimental Biology 2012
נושאים:
Research Communications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448769/
https://ncbi.nlm.nih.gov/pubmed/22798424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-207431
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