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Intracellular Ubiquitylation of the Epithelial Na(+) Channel Controls Extracellular Proteolytic Channel Activation via Conformational Change
The epithelial Na(+) channel ENaC is a key player in the maintenance of whole body Na(+) balance, and consequently of blood pressure. It is tightly regulated by numerous signaling pathways including ubiquitylation via the ubiquitin-protein ligase Nedd4-2. This mechanism is itself under the control o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024735/ https://ncbi.nlm.nih.gov/pubmed/21084303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.176156 |
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