The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na(+) Channel

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial cells. Absence of cAMP-mediated Cl(−) secretion in CF airways causes poorly hydrated airway surfaces in CF patients, a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gentzsch, Martina, Dang, Hong, Dang, Yan, Garcia-Caballero, Agustin, Suchindran, Hamsa, Boucher, Richard C., Stutts, M. Jackson
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Membrane Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952223/
https://ncbi.nlm.nih.gov/pubmed/20709758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155259
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