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The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na(+) Channel

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial cells. Absence of cAMP-mediated Cl(−) secretion in CF airways causes poorly hydrated airway surfaces in CF patients, a...

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書誌詳細
主要な著者: Gentzsch, Martina, Dang, Hong, Dang, Yan, Garcia-Caballero, Agustin, Suchindran, Hamsa, Boucher, Richard C., Stutts, M. Jackson
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952223/
https://ncbi.nlm.nih.gov/pubmed/20709758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155259
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