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The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na(+) Channel
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) that prevent its proper folding and trafficking to the apical membrane of epithelial cells. Absence of cAMP-mediated Cl(−) secretion in CF airways causes poorly hydrated airway surfaces in CF patients, a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952223/ https://ncbi.nlm.nih.gov/pubmed/20709758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.155259 |
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