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Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel

The epithelial sodium channel (ENaC) mediates sodium absorption in lung, kidney, and colon epithelia. Channels in the ENaC/degenerin family possess an extracellular region that senses physicochemical changes in the extracellular milieu and allosterically regulates the channel opening. Proteolytic cl...

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Foilsithe in:J Biol Chem
Main Authors: Shobair, Mahmoud, Popov, Konstantin I., Dang, Yan L., He, Hong, Stutts, M. Jackson, Dokholyan, Nikolay V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846138/
https://ncbi.nlm.nih.gov/pubmed/29358325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000604
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