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Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel
The epithelial sodium channel (ENaC) mediates sodium absorption in lung, kidney, and colon epithelia. Channels in the ENaC/degenerin family possess an extracellular region that senses physicochemical changes in the extracellular milieu and allosterically regulates the channel opening. Proteolytic cl...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846138/ https://ncbi.nlm.nih.gov/pubmed/29358325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000604 |
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