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Light-regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP
[Image: see text] We developed a new system for light-induced protein dimerization in living cells using a novel photocaged analog of rapamycin (pRap) together with an engineered rapamycin binding domain (iFKBP). Using focal adhesion kinase as a target, we demonstrated successful light-mediated regu...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3133816/ https://ncbi.nlm.nih.gov/pubmed/21162531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109630v |
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