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Engineering extrinsic disorder to control protein activity in living cells
Optogenetic and chemogenetic control of proteins has revealed otherwise inaccessible facets of signaling dynamics. Here we use light or ligand-sensitive domains to modulate the structural disorder of diverse proteins, thereby generating robust allosteric switches. Sensory domains were inserted into...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5362825/ https://ncbi.nlm.nih.gov/pubmed/27980211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah3404 |
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