Rational design of a ligand-controlled protein conformational switch

Design of a regulatable multistate protein is a challenge for protein engineering. Here we design a protein with a unique topology, called uniRapR, whose conformation is controlled by the binding of a small molecule. We confirm switching and control ability of uniRapR in silico, in vitro, and in viv...

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Bibliografiske detaljer
Main Authors: Dagliyan, Onur, Shirvanyants, David, Karginov, Andrei V., Ding, Feng, Fee, Lanette, Chandrasekaran, Srinivas N., Freisinger, Christina M., Smolen, Gromoslaw A., Huttenlocher, Anna, Hahn, Klaus M., Dokholyan, Nikolay V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637791/
https://ncbi.nlm.nih.gov/pubmed/23569285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218319110
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