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Engineering Pak1 allosteric switches
p21-activated kinases (PAKs) are important regulators of cell motility and morphology. It has been challenging to interrogate their functions because cells adapt to genetic manipulation of PAK, and because inhibitors act on multiple PAK isoforms. Here we describe genetically encoded PAK1 analogues t...
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| Publicado no: | ACS Synth Biol |
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| Principais autores: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5562282/ https://ncbi.nlm.nih.gov/pubmed/28365983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.6b00359 |
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