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FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions
Guanine-nucleotide dissociation inhibitors (GDI) are negative regulators of Rho family GTPases that sequester the GTPases away from the membrane. Here we ask how GDI-Cdc42 interaction regulates localized Cdc42 activation for cell motility. The sensitivity of cells to overexpression of Rho family pat...
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| Gepubliceerd in: | Nat Chem Biol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030135/ https://ncbi.nlm.nih.gov/pubmed/27501396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2145 |
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