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Allosteric activation of kinases: Design and application of RapR kinases

Here we describe a method for the engineered regulation of protein kinases in living cells, the design and application of RapR (rapamycin regulated) kinases. The RapR kinase method enables activation of kinases with high specificity and precise temporal control. Insertion of an engineered allosteric...

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Detalhes bibliográficos
Main Authors: Karginov, Andrei V., Hahn, Klaus M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269071/
https://ncbi.nlm.nih.gov/pubmed/22161545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/0471143030.cb1413s53
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