Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system

di Mitchell, Jane A, Kirkby, Nicholas S
Pubblicato in Br J Pharmacol (2018)

Imaging of Tissue-specific and Temporal Activation of GPCR Signaling using DREADD Knock-In Mice

di Akhmedov, Dmitry, Kirkby, Nicholas S., Mitchell, Jane A., Berdeaux, Rebecca
Pubblicato in Methods Mol Biol (2019)

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy

di Hoefer, Thomas, Armstrong, Paul C., Finsterbusch, Michaela, Chan, Melissa V., Kirkby, Nicholas S., Warner, Timothy D.
Pubblicato in Arterioscler Thromb Vasc Biol (2015)

Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells

di Ahmetaj-Shala, Blerina, Vaja, Ricky, Atanur, Santosh S., George, Peter M., Kirkby, Nicholas S., Mitchell, Jane A.
Pubblicato in JACC Basic Transl Sci (2020)

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse

di Armstrong, Paul C., Kirkby, Nicholas S., Zain, Zetty N., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.
Pubblicazione 2011

Quantitative 3-Dimensional Imaging of Murine Neointimal and Atherosclerotic Lesions by Optical Projection Tomography

di Kirkby, Nicholas S., Low, Lucinda, Seckl, Jonathan R., Walker, Brian R., Webb, David J., Hadoke, Patrick W. F.
Pubblicazione 2011

Differential role of pannexin-1/ATP/P2X(7) axis in IL-1β release by human monocytes

di Parzych, Katarzyna, Zetterqvist, Anna V., Wright, William R., Kirkby, Nicholas S., Mitchell, Jane A., Paul-Clark, Mark J.
Pubblicato in FASEB J (2017)

COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks

di Kirkby, Nicholas S., Lundberg, Martina H., Wright, William R., Warner, Timothy D., Paul-Clark, Mark J., Mitchell, Jane A.
Pubblicazione 2014

Role of prostacyclin in pulmonary hypertension

di Mitchell, Jane A., Ahmetaj-Shala, Blerina, Kirkby, Nicholas S., Wright, William R., Mackenzie, Louise S., Reed, Daniel M., Mohamed, Nura
Pubblicato in Glob Cardiol Sci Pract (2014)

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction

di Armstrong, Paul C. J, Kirkby, Nicholas S., Chan, Melissa V., Finsterbusch, Michaela, Hogg, Nancy, Nourshargh, Sussan, Warner, Timothy D.
Pubblicato in Blood (2015)

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1

di Rauzi, Francesca, Kirkby, Nicholas S., Edin, Matthew L., Whiteford, James, Zeldin, Darryl C., Mitchell, Jane A., Warner, Timothy D.
Pubblicato in FASEB J (2016)

IN THE PRESENCE OF STRONG P2Y(12) RECEPTOR BLOCKADE, ASPIRIN PROVIDES LITTLE ADDITIONAL INHIBITION OF PLATELET AGGREGATION

di Armstrong, Paul C.J., Leadbeater, Philip D., Chan, Melissa V., Kirkby, Nicholas S., Jakubowski, Joseph A., Mitchell, Jane A., Warner, Timothy D.
Pubblicazione 2011

Blockade of the purinergic P2Y(12) receptor greatly increases the platelet inhibitory actions of nitric oxide

di Kirkby, Nicholas S., Lundberg, Martina H., Chan, Melissa V., Vojnovic, Ivana, Solomon, Antonia B., Emerson, Michael, Mitchell, Jane A., Warner, Timothy D.
Pubblicazione 2013

Generation and 3-Dimensional Quantitation of Arterial Lesions in Mice Using Optical Projection Tomography

di Kirkby, Nicholas S., Low, Lucinda, Wu, Junxi, Miller, Eileen, Seckl, Jonathan R., Walker, Brian R., Webb, David J., Hadoke, Patrick W. F.
Pubblicato in J Vis Exp (2015)

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies()

di Kirkby, Nicholas S., Zaiss, Anne K., Wright, William R., Jiao, Jing, Chan, Melissa V., Warner, Timothy D., R. Herschman, Harvey, Mitchell, Jane A.
Pubblicazione 2013

Ibuprofen arginate retains eNOS substrate activity and reverses endothelial dysfunction: implications for the COX-2/ADMA axis

di Kirkby, Nicholas S., Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime H., Sampaio, Walkyria, Etelvino, Gisele, Leão, Nádia Miricéia, Santos, Robson A., Mitchell, Jane A.
Pubblicato in FASEB J (2016)

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

di Mitchell, Jane A., Shala, Fisnik, Elghazouli, Youssef, Warner, Timothy D., Gaston-Massuet, Carles, Crescente, Marilena, Armstrong, Paul C., Herschman, Harvey R., Kirkby, Nicholas S.
Pubblicato in Circ Res (2019)

Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury

di Duthie, Karolina M, Hadoke, Patrick W F, Kirkby, Nicholas S, Miller, Eileen, Ivy, Jessica R, McShane, John F, Lim, Win Gel, Webb, David J
Pubblicato in Br J Pharmacol (2015)

A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering

di Ahmetaj‐Shala, Blerina, Kawai, Ryota, Marei, Isra, Nikolakopoulou, Zacharoula, Shih, Chih‐Chin, Konain, Bhatti, Reed, Daniel M., Mongey, Róisín, Kirkby, Nicholas S., Mitchell, Jane A.
Pubblicato in FASEB J (2019)

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

di d’Emmanuele di Villa Bianca, Roberta, Mitidieri, Emma, Di Minno, Matteo N. D., Kirkby, Nicholas S., Warner, Timothy D., Di Minno, Giovanni, Cirino, Giuseppe, Sorrentino, Raffaella
Pubblicazione 2013