Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A(2), both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate any antithrombotic role for COX1-derived prostacyclin from the prothrombotic effects...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Mitchell, Jane A., Shala, Fisnik, Elghazouli, Youssef, Warner, Timothy D., Gaston-Massuet, Carles, Crescente, Marilena, Armstrong, Paul C., Herschman, Harvey R., Kirkby, Nicholas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791564/
https://ncbi.nlm.nih.gov/pubmed/31510878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.314927
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