LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression

There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found that COX-1, not COX-2, is responsible for vascula...

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Détails bibliographiques
Auteurs principaux: Kirkby, Nicholas S., Zaiss, Anne K., Urquhart, Paula, Jiao, Jing, Austin, Philip J., Al-Yamani, Malak, Lundberg, Martina H., MacKenzie, Louise S., Warner, Timothy D., Nicolaou, Anna, Herschman, Harvey R., Mitchell, Jane A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711559/
https://ncbi.nlm.nih.gov/pubmed/23874970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069524
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