Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Prostacyclin is an antithrombotic hormone produced by the endothelium, whose production is dependent on cyclooxygenase (COX) enzymes of which two isoforms exist. It is widely believed that COX-2 drives prostacyclin production and that this explains the cardiovascular toxicity associated with COX-2 i...

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Detalhes bibliográficos
Main Authors: Kirkby, Nicholas S., Lundberg, Martina H., Harrington, Louise S., Leadbeater, Philip D. M., Milne, Ginger L., Potter, Claire M. F., Al-Yamani, Malak, Adeyemi, Oladipupo, Warner, Timothy D., Mitchell, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491520/
https://ncbi.nlm.nih.gov/pubmed/23045674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209192109
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