COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks

Cyxlo-oxygenase (COX)-2 inhibitors, including traditional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with increased cardiovascular side effects, including myocardial infarction. We and others have shown that COX-1 and not COX-2 drives vascular prostacyclin in the healthy cardiovasc...

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Detalhes bibliográficos
Main Authors: Kirkby, Nicholas S., Lundberg, Martina H., Wright, William R., Warner, Timothy D., Paul-Clark, Mark J., Mitchell, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041570/
https://ncbi.nlm.nih.gov/pubmed/24887395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098165
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