Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation

Endothelial cyclooxygenase-1–derived prostanoids, including prostacyclin, have clear cardioprotective roles associated with their anti-thrombotic potential but have also been suggested to have paradoxical pathological activities within arteries. To date it has not been possible to test the importanc...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Mitchell, Jane A., Shala, Fisnik, Pires, Maria Elisa Lopes, Loy, Rachel Y., Ravendren, Andrew, Benson, Joshua, Urquhart, Paula, Nicolaou, Anna, Herschman, Harvey R., Kirkby, Nicholas S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978428/
https://ncbi.nlm.nih.gov/pubmed/33741600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf6054
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