Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

Endothelial cells (ECs) and platelets, which respectively produce antithrombotic prostacyclin and prothrombotic thromboxane A(2), both express COX1 (cyclooxygenase1). Consequently, there has been no way to delineate any antithrombotic role for COX1-derived prostacyclin from the prothrombotic effects...

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Dades bibliogràfiques
Publicat a:Circ Res
Autors principals: Mitchell, Jane A., Shala, Fisnik, Elghazouli, Youssef, Warner, Timothy D., Gaston-Massuet, Carles, Crescente, Marilena, Armstrong, Paul C., Herschman, Harvey R., Kirkby, Nicholas S.
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2019
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791564/
https://ncbi.nlm.nih.gov/pubmed/31510878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.314927
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