Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections

door Prichard, Mark N., Keith, Kathy A., Quenelle, Debra C., Kern, Earl R.
Gepubliceerd in 2006

Evaluation of Nucleoside Phosphonates and Their Analogs and Prodrugs for Inhibition of Orthopoxvirus Replication

door Keith, Kathy A., Hitchcock, Michael J. M., Lee, William A., Holý, Antonin, Kern, Earl R.
Gepubliceerd in 2003

5-(Dimethoxymethyl)-2′-Deoxyuridine: A Novel Gem Diether Nucleoside with Anti-Orthopoxvirus Activity

door Fan, Xuesen, Zhang, Xinying, Zhou, Longhu, Keith, Kathy A., Kern, Earl R., Torrence, Paul F.
Gepubliceerd in J Med Chem (2006)

Enhanced Inhibition of Orthopoxvirus Replication In Vitro by Alkoxyalkyl Esters of Cidofovir and Cyclic Cidofovir

door Kern, Earl R., Hartline, Caroll, Harden, Emma, Keith, Kathy, Rodriguez, Natalie, Beadle, James R., Hostetler, Karl Y.
Gepubliceerd in 2002

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro

door Keith, Kathy A., Wan, William B., Ciesla, Stephanie L., Beadle, James R., Hostetler, Karl Y., Kern, Earl R.
Gepubliceerd in 2004

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

door Prichard, Mark N, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Moyer, Richard W, Turner, Peter C
Gepubliceerd in 2008

Toward Orthopoxvirus Countermeasures: A Novel Heteromorphic Nucleoside of Unusual Structure

door Fan, Xuesen, Zhang, Xinying, Zhou, Longhu, Keith, Kathy A., Prichard, Mark N., Kern, Earl R., Torrence, Paul F.
Gepubliceerd in J Med Chem (2006)

Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice

door Quenelle, Debra C., Buller, R. M. L., Parker, Scott, Keith, Kathy A., Hruby, Dennis E., Jordan, Robert, Kern, Earl R.
Gepubliceerd in 2007

Synthesis and Antiviral Evaluation of Alkoxyalkyl Phosphate Conjugates of Cidofovir and Adefovir

door Ruiz, Jacqueline C., Beadle, James R., Aldern, Kathy A., Keith, Kathy A., Hartline, Caroll B., Kern, Earl R., Hostetler, Karl Y.
Gepubliceerd in 2006

Activities of Certain 5-Substituted 4′-Thiopyrimidine Nucleosides against Orthopoxvirus Infections

door Kern, Earl R., Prichard, Mark N., Quenelle, Debra C., Keith, Kathy A., Tiwari, Kamal N., Maddry, Joseph A., Secrist, John A.
Gepubliceerd in 2009

Identification of Protein-Protein Interaction Inhibitors Targeting Vaccinia Virus Processivity Factor for Development of Antiviral Agents

door Schormann, Norbert, Sommers, Charnell Inglis, Prichard, Mark N., Keith, Kathy A., Noah, James W., Nuth, Manunya, Ricciardi, Robert P., Chattopadhyay, Debasish
Gepubliceerd in 2011

Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses

door Quenelle, Debra C., Prichard, Mark N., Keith, Kathy A., Hruby, Dennis E., Jordan, Robert, Painter, George R., Robertson, Alice, Kern, Earl R.
Gepubliceerd in 2007

Isolation and characterization of cidofovir resistant vaccinia viruses

door Becker, Marie N, Obraztsova, Maria, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Prichard, Mark N, Luo, Ming, Moyer, Richard W
Gepubliceerd in 2008

SYNTHESIS, METABOLIC STABILITY AND ANTIVIRAL EVALUATION OF VARIOUS ALKOXYALKYL ESTERS OF CIDOFOVIR AND (S)-[3-HYDROXY-2-(PHOSPHONOMETHOXY)PROPYL]ADENINE

door Ruiz, Jacqueline, Beadle, James R., Buller, R. Mark, Schreiwer, Jill, Prichard, Mark N., Keith, Kathy A., Lewis, Kenneth C., Hostetler, Karl Y.
Gepubliceerd in 2011

Effect of Oral Treatment with Hexadecyloxypropyl-[(S)-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [(S)-HPMPA] or Octadecyloxyethyl-(S)-HPMPA on Cowpox or Vaccinia Virus Infect...

door Quenelle, Debra C., Collins, Deborah J., Herrod, Bridgett P., Keith, Kathy A., Trahan, Julissa, Beadle, James R., Hostetler, Karl Y., Kern, Earl R.
Gepubliceerd in 2007

Antiviral Evaluation of Octadecyloxyethyl Esters of (S)-3-Hydroxy-2-(phosphonomethoxy)propyl Nucleosides Against Herpesviruses and Orthopoxviruses

door Valiaeva, Nadejda, Prichard, Mark N., Buller, R. Mark, Beadle, James R., Hartline, Caroll B., Keith, Kathy A., Schriewer, Jill, Trahan, Julissa, Hostetler, Karl Y.
Gepubliceerd in 2009

Antiviral Activities of Novel 5-Phosphono-Pent-2-en-1-yl Nucleosides and Their Alkoxyalkyl Phosphonoesters

door Choo, Hyunah, Beadle, James R., Kern, Earl R., Prichard, Mark N., Keith, Kathy A., Hartline, Caroll B., Trahan, Julissa, Aldern, Kathy A., Korba, Brent E., Hostetler, Karl Y.
Gepubliceerd in 2007

Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase

door Prichard, Mark N., Keith, Kathy A., Johnson, Mary P., Harden, Emma A., McBrayer, Alexis, Luo, Ming, Qiu, Shihong, Chattopadhyay, Debasish, Fan, Xuesen, Torrence, Paul F., Kern, Earl R.
Gepubliceerd in 2007

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides

door Williams, John D., Khan, Atiyya R., Harden, Emma A., Hartline, Caroll B., Jefferson, Geraldine M., Keith, Kathy A., Prichard, Mark N., Zemlicka, Jiri, Peet, Norton P., Bowlin, Terry L.
Gepubliceerd in 2012

New Small Molecule Entry Inhibitors Targeting Hemagglutinin-Mediated Influenza A Virus Fusion

door Basu, Arnab, Antanasijevic, Aleksandar, Wang, Minxiu, Li, Bing, Mills, Debra M., Ames, Jessica A., Nash, Peter J., Williams, John D., Peet, Norton P., Moir, Donald T., Prichard, Mark N., Keith, Kathy A., Barnard, Dale L., Caffrey, Michael, Rong, Lijun, Bowlin, Terry L.
Gepubliceerd in 2014