Assay for Isolation of Inhibitors of Her2-Kinase Expression

Por Chiosis, Gabriela, Keeton, Adam B.
Publicado em 2009

The RAS-effector interaction as a drug target

Por Keeton, Adam B., Salter, E. Alan, Piazza, Gary A.
Publicado no Cancer Res (2017)

Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells

Por Franklin, J. Lee, Keeton, Adam B, Bortoff, Katherine D., Messina, Joseph L.
Publicado em 2008

Anti-inflammatory action of insulin via induction of Gadd45-β transcription by the mTOR signaling pathway

Por Bortoff, Katherine D, Keeton, Adam B, Franklin, J Lee, Messina, Joseph L
Publicado em 2010

Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells

Por Prasain, Jeevan K., Rajbhandari, Rajani, Keeton, Adam B., Piazza, Gary A., Barnes, Stephen
Publicado no Food Funct (2016)

Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation

Por Lu, Wenyan, Tinsley, Heather N., Keeton, Adam, Qu, Zhican, Piazza, Gary A., Li, Yonghe
Publicado em 2008

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

Por Awadallah, Fadi M., Piazza, Gary A., Gary, Bernard D., Keeton, Adam B., Canzoneri, Joshua C.
Publicado no Eur J Med Chem (2013)

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin mediated transcription in human breast tumor cells

Por Tinsley, Heather N., Gary, Bernard D., Keeton, Adam B., Lu, Wenyan, Li, Yonghe, Piazza, Gary A.
Publicado em 2011

β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

Por Lee, Kevin, Lindsey, Ashley S., Li, Nan, Gary, Bernard, Andrews, Joel, Keeton, Adam B., Piazza, Gary A.
Publicado no Oncotarget (2015)

New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention

Por Tinsley, Heather N., Grizzle, William E., Abadi, Ashraf, Keeton, Adam, Zhu, Bing, Xi, Yaguang, Piazza, Gary A.
Publicado em 2013

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

Por Attia, Mohamed I., Eldehna, Wagdy M., Afifi, Samar A., Keeton, Adam B., Piazza, Gary A., Abdel-Aziz, Hatem A.
Publicado no PLoS One (2017)

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by PDE5 inhibition, elevation of cGMP, and activation of PKG

Por Tinsley, Heather N., Gary, Bernard D., Keeton, Adam B., Zhang, Wei, Abadi, Ashraf H., Reynolds, Robert C., Piazza, Gary A.
Publicado em 2009

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

Por Whitt, Jason D., Keeton, Adam B., Gary, Bernard D., Sklar, Larry A., Sodani, Kamlesh, Chen, Zhe-Sheng, Piazza, Gary A.
Publicado no J Biomed Res (2016)

Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDs is associated with PDE5 inhibition

Por Tinsley, Heather N., Gary, Bernard D., Thaiparambil, Jose, Li, Nan, Lu, Wenyan, Li, Yonghe, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Publicado em 2010

Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents

Por Abadi, Ashraf H., Abouel-Ella, Dalal A., Ahmed, Nermin S., Gary, Bernard D., Thaiparambil, Jose T., Tinsley, Heather N., Keeton, Adam B., Piazza, Gary A.
Publicado no Arzneimittelforschung (2009)

Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention

Por Aboul-Fadl, Tarek, Al-Hamad, Suliman S., Lee, Kevin, Li, Nan, Gary, Bernard D., Keeton, Adam B., Piazza, Gary A., Abdel-Hamid, Mohammed K.
Publicado no Med Chem Res (2014)

A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy

Por Gurpinar, Evrim, Grizzle, William E., Shacka, John J., Mader, Burton J., Li, Nan, Piazza, Nicholas A., Russo, Suzanne, Keeton, Adam B., Piazza, Gary A.
Publicado em 2013

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling

Por Abdel-Aziz, Hatem A, Eldehna, Wagdy M, Keeton, Adam B, Piazza, Gary A, Kadi, Adnan A, Attwa, Mohamed W, Abdelhameed, Ali S, Attia, Mohamed I
Publicado no Drug Des Devel Ther (2017)

NSAIDs: Old Drugs Reveal New Anticancer Targets

Por Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Whitt, Jason D., Gary, Bernard D., Mathew, Bini, Singh, Raj, Grizzle, William E., Reynolds, Robert C.
Publicado em 2010

A High-Throughput Screen with Isogenic PTEN(+/+) and PTEN(−/−) Cells Identifies CID1340132 as a Novel Compound That Induces Apoptosis in PTEN and PIK3CA Mutant Human Cancer Cells...

Por Li, Hui-Fang, Keeton, Adam, Vitolo, Michele, Maddox, Clinton, Rasmussen, Lynn, Hobrath, Judith, White, E. Lucille, Park, Ben Ho, Piazza, Gary A., Kim, Jung-Sik, Waldman, Todd
Publicado no J Biomol Screen (2011)