A High-Throughput Screen with Isogenic PTEN(+/+) and PTEN(−/−) Cells Identifies CID1340132 as a Novel Compound That Induces Apoptosis in PTEN and PIK3CA Mutant Human Cancer Cells

The PTEN tumor suppressor gene is one of the most commonly mutated genes in human cancer. Because inactivation of PTEN is a somatic event, PTEN mutations represent an important genetic difference between cancer cells and normal cells and therefore a potential anticancer drug target. However, it rema...

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Publicado no:J Biomol Screen
Main Authors: Li, Hui-Fang, Keeton, Adam, Vitolo, Michele, Maddox, Clinton, Rasmussen, Lynn, Hobrath, Judith, White, E. Lucille, Park, Ben Ho, Piazza, Gary A., Kim, Jung-Sik, Waldman, Todd
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381441/
https://ncbi.nlm.nih.gov/pubmed/21335596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110397357
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