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A High-Throughput Screen with Isogenic PTEN(+/+) and PTEN(−/−) Cells Identifies CID1340132 as a Novel Compound That Induces Apoptosis in PTEN and PIK3CA Mutant Human Cancer Cells
The PTEN tumor suppressor gene is one of the most commonly mutated genes in human cancer. Because inactivation of PTEN is a somatic event, PTEN mutations represent an important genetic difference between cancer cells and normal cells and therefore a potential anticancer drug target. However, it rema...
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| Udgivet i: | J Biomol Screen |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381441/ https://ncbi.nlm.nih.gov/pubmed/21335596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057110397357 |
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