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PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells
Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacolo...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384184/ https://ncbi.nlm.nih.gov/pubmed/15466180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-1767 |
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