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PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells
Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacolo...
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| Udgivet i: | Cancer Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4384184/ https://ncbi.nlm.nih.gov/pubmed/15466180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-1767 |
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