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PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells

Following DNA damage, human cells arrest primarily in the G(1) and G(2) phases of the cell cycle. Here, we show that after irradiation, human cancer cells with targeted deletion of PTEN or naturally occurring PTEN mutations can exert G(1) and G(2) arrests but are unable to arrest in size. Pharmacolo...

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Bibliografische gegevens
Gepubliceerd in:Cancer Res
Hoofdauteurs: Lee, Carolyn, Kim, Jung-Sik, Waldman, Todd
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384184/
https://ncbi.nlm.nih.gov/pubmed/15466180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-1767
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