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Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention
A structure-based medicinal chemistry strategy was applied to design new naproxen derivatives that show growth inhibitory activity against human colon tumor cells through a cyclooxygenase (COX)-independent mechanism. In vitro testing of the synthesized compounds against the human HT-29 colon tumor c...
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| Publicado no: | Med Chem Res |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993210/ https://ncbi.nlm.nih.gov/pubmed/27559271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-014-0979-z |
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