Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

od Lachowski, Dariusz, Cortes, Ernesto, Pink, Daniel, Chronopoulos, Antonios, Karim, Saadia A., P. Morton, Jennifer, del Río Hernández, Armando E.
izdano v Sci Rep (2017)

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

od Zheng, Liang, MacKenzie, Elaine D, Karim, Saadia A, Hedley, Ann, Blyth, Karen, Kalna, Gabriela, Watson, David G, Szlosarek, Peter, Frezza, Christian, Gottlieb, Eyal
Izdano 2013

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

od McGhee, Ewan J, Morton, Jennifer P, Von Kriegsheim, Alex, Schwarz, Juliane P, Karim, Saadia A, Carragher, Neil O, Sansom, Owen J, Anderson, Kurt I, Timpson, Paul
Izdano 2011

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

od Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P., Sansom, Owen J., Kamphorst, Jurre J.
izdano v Cell Rep (2020)

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

od Steele, Colin W, Karim, Saadia A, Foth, Mona, Rishi, Loveena, Leach, Joshua DG, Porter, Ross J, Nixon, Colin, Jeffry Evans, TR, Carter, C Ross, Nibbs, Robert JB, Sansom, Owen J, Morton, Jennifer P
izdano v J Pathol (2015)

Genomic instability in mutant p53 cancer cells upon entotic engulfment

od Mackay, Hannah L., Moore, David, Hall, Callum, Birkbak, Nicolai J., Jamal-Hanjani, Mariam, Karim, Saadia A., Phatak, Vinaya M., Piñon, Lucia, Morton, Jennifer P., Swanton, Charles, Le Quesne, John, Muller, Patricia A. J.
izdano v Nat Commun (2018)

Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment

od Mackay, Hannah L., Moore, David, Hall, Callum, Birkbak, Nicolai J., Jamal-Hanjani, Mariam, Karim, Saadia A., Phatak, Vinaya M., Piñon, Lucia, Morton, Jennifer P., Swanton, Charles, Le Quesne, John, Muller, Patricia A. J.
izdano v Nat Commun (2018)

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

od Morton, Jennifer P., Timpson, Paul, Karim, Saadia A., Ridgway, Rachel A., Athineos, Dimitris, Doyle, Brendan, Jamieson, Nigel B., Oien, Karin A., Lowy, Andrew M., Brunton, Valerie G., Frame, Margaret C., Evans, T. R. Jeffry, Sansom, Owen J.
Izdano 2009

Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models

od Ahmed, Ahmed A., Angell, Richard, Oxenford, Sally, Worthington, Jenny, Williams, Nicole, Barton, Naomi, Fowler, Thomas G., O’Flynn, Daniel E., Sunose, Mihiro, McConville, Matthew, Vo, Tam, Wilson, W. David, Karim, Saadia A., Morton, Jennifer P., Neidle, Stephen
izdano v ACS Med Chem Lett (2020)

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

od Morton, Jennifer P., Jamieson, Nigel B., Karim, Saadia A., Athineos, Dimitris, Ridgway, Rachel A., Nixon, Colin, McKay, Colin J., Carter, Ross, Brunton, Valerie G., Frame, Margaret C., Ashworth, Alan, Oien, Karin A., Evans, T.R. Jeffry, Sansom, Owen J.
Izdano 2010

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

od Timpson, Paul, McGhee, Ewan J., Morton, Jennifer P., von Kriegsheim, Alex, Schwarz, Juliane P., Karim, Saadia A., Doyle, Brendan, Quinn, Jean A., Carragher, Neil O., Edward, Mike, Olson, Michael F., Frame, Margaret C., Brunton, Valerie G., Sansom, Owen J., Anderson, Kurt I.
Izdano 2011

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

od Nielsen, Sebastian R., Strøbech, Jan E., Horton, Edward R., Jackstadt, Rene, Laitala, Anu, Bravo, Marina C., Maltese, Giorgia, Jensen, Adina R. D., Reuten, Raphael, Rafaeva, Maria, Karim, Saadia A., Hwang, Chang-Il, Arnes, Luis, Tuveson, David A., Sansom, Owen J., Morton, Jennifer P., Erler, Janine T.
izdano v Nat Commun (2021)

mTORC2 signaling drives the development and progression of pancreatic cancer

od Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, TR Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J., Klimstra, David S., Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P
izdano v Cancer Res (2016)

Fascin Is Regulated by Slug, Promotes Progression of Pancreatic Cancer in Mice, and Is Associated With Patient Outcomes

od Li, Ang, Morton, Jennifer P., Ma, YaFeng, Karim, Saadia A., Zhou, Yan, Faller, William J., Woodham, Emma F., Morris, Hayley T., Stevenson, Richard P., Juin, Amelie, Jamieson, Nigel B., MacKay, Colin J., Carter, C. Ross, Leung, Hing Y., Yamashiro, Shigeko, Blyth, Karen, Sansom, Owen J., Machesky, Laura M.
Izdano 2014

Repression of the Type I Interferon pathway underlies MYC & KRAS-dependent evasion of NK & B cells in Pancreatic Ductal Adenocarcinoma

od Muthalagu, Nathiya, Monteverde, Tiziana, Raffo-Iraolagoitia, Ximena, Wiesheu, Robert, Whyte, Declan, Hedley, Ann, Laing, Sarah, Kruspig, Björn, Upstill-Goddard, Rosanna, Shaw, Robin, Neidler, Sarah, Rink, Curtis, Karim, Saadia A., Gyuraszova, Katarina, Nixon, Colin, Clark, William, Biankin, Andrew V., Carlin, Leo M., Coffelt, Seth B., Sansom, Owen J., Morton, Jennifer P., Murphy, Daniel J.
izdano v Cancer Discov (2020)

Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

od Dikovskaya, Dina, Cole, John J., Mason, Susan M., Nixon, Colin, Karim, Saadia A., McGarry, Lynn, Clark, William, Hewitt, Rachael N., Sammons, Morgan A., Zhu, Jiajun, Athineos, Dimitris, Leach, Joshua D.G., Marchesi, Francesco, van Tuyn, John, Tait, Stephen W., Brock, Claire, Morton, Jennifer P., Wu, Hong, Berger, Shelley L., Blyth, Karen, Adams, Peter D.
izdano v Cell Rep (2015)

Mutant p53(R270H) drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma

od Schofield, Heather K., Zeller, Jörg, Espinoza, Carlos, Halbrook, Christopher J., del Vecchio, Annachiara, Magnuson, Brian, Fabo, Tania, Daylan, Ayse Ece Cali, Kovalenko, Ilya, Lee, Ho-Joon, Yan, Wei, Feng, Ying, Karim, Saadia A., Kremer, Daniel M., Kumar-Sinha, Chandan, Lyssiotis, Costas A., Ljungman, Mats, Morton, Jennifer P., Galbán, Stefanie, Fearon, Eric R., Pasca di Magliano, Marina
izdano v JCI Insight (2018)

Targeting mTOR dependency in pancreatic cancer

od Morran, Douglas C, Wu, Jianmin, Jamieson, Nigel B, Mrowinska, Agata, Kalna, Gabriela, Karim, Saadia A, Au, Amy Y M, Scarlett, Christopher J, Chang, David K, Pajak, Malgorzata Z, Oien, Karin A, McKay, Colin J, Carter, C Ross, Gillen, Gerry, Champion, Sue, Pimlott, Sally L, Anderson, Kurt I, Evans, T R Jeffry, Grimmond, Sean M, Biankin, Andrew V, Sansom, Owen J, Morton, Jennifer P
Izdano 2014

mTORC1 mediated translational elongation limits intestinal tumour initiation and growth

od Faller, William J., Jackson, Thomas J., Knight, John RP, Ridgway, Rachel A., Jamieson, Thomas, Karim, Saadia A., Jones, Carolyn, Radulescu, Sorina, Huels, David J., Myant, Kevin B., Dudek, Kate M., Casey, Helen A., Scopelliti, Alessandro, Cordero, Julia B., Vidal, Marcos, Pende, Mario, Ryazanov, Alexey G., Sonenberg, Nahum, Meyuhas, Oded, Hall, Michael N., Bushell, Martin, Willis, Anne E., Sansom, Owen J.
izdano v Nature (2014)

CSF1R(+) Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

od Candido, Juliana B., Morton, Jennifer P., Bailey, Peter, Campbell, Andrew D., Karim, Saadia A., Jamieson, Thomas, Lapienyte, Laura, Gopinathan, Aarthi, Clark, William, McGhee, Ewan J., Wang, Jun, Escorcio-Correia, Monica, Zollinger, Raphael, Roshani, Rozita, Drew, Lisa, Rishi, Loveena, Arkell, Rebecca, Evans, T.R. Jeffry, Nixon, Colin, Jodrell, Duncan I., Wilkinson, Robert W., Biankin, Andrew V., Barry, Simon T., Balkwill, Frances R., Sansom, Owen J.
izdano v Cell Rep (2018)