Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest

Oncogene-induced senescence (OIS) is a tumor suppression mechanism that blocks cell proliferation in response to oncogenic signaling. OIS is frequently accompanied by multinucleation; however, the origin of this is unknown. Here, we show that multinucleate OIS cells originate mostly from failed mito...

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Publicado no:Cell Rep
Main Authors: Dikovskaya, Dina, Cole, John J., Mason, Susan M., Nixon, Colin, Karim, Saadia A., McGarry, Lynn, Clark, William, Hewitt, Rachael N., Sammons, Morgan A., Zhu, Jiajun, Athineos, Dimitris, Leach, Joshua D.G., Marchesi, Francesco, van Tuyn, John, Tait, Stephen W., Brock, Claire, Morton, Jennifer P., Wu, Hong, Berger, Shelley L., Blyth, Karen, Adams, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562906/
https://ncbi.nlm.nih.gov/pubmed/26299965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.055
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