Genomic instability in mutant p53 cancer cells upon entotic engulfment

Cell-in-cell (CIC) structures are commonly seen in tumours. Their biological significance remains unclear, although they have been associated with more aggressive tumours. Here we report that mutant p53 promotes CIC via live cell engulfment. Engulfed cells physically interfere in cell divisions of h...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mackay, Hannah L., Moore, David, Hall, Callum, Birkbak, Nicolai J., Jamal-Hanjani, Mariam, Karim, Saadia A., Phatak, Vinaya M., Piñon, Lucia, Morton, Jennifer P., Swanton, Charles, Le Quesne, John, Muller, Patricia A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076230/
https://ncbi.nlm.nih.gov/pubmed/30076358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05368-1
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