Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane

TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastasis and chemoresistance. Previously, we uncovered a role for...

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Publicado no:Cell Death Dis
Main Authors: Phatak, Vinaya, von Grabowiecki, Yannick, Janus, Justyna, Officer, Leah, Behan, Caron, Aschauer, Lydia, Pinon, Lucia, Mackay, Hannah, Zanivan, Sara, Norman, Jim C., Kelly, Michael, Le Quesne, John, Muller, Patricia A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904762/
https://ncbi.nlm.nih.gov/pubmed/33627632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03497-y
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