Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models

[Image: see text] Targeting of genomic quadruplexes is an approach to treating complex human cancers. We describe a series of tetra-substituted naphthalene diimide (ND) derivatives with a phenyl substituent directly attached to the ND core. The lead compound (SOP1812) has 10 times superior cellular...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Ahmed, Ahmed A., Angell, Richard, Oxenford, Sally, Worthington, Jenny, Williams, Nicole, Barton, Naomi, Fowler, Thomas G., O’Flynn, Daniel E., Sunose, Mihiro, McConville, Matthew, Vo, Tam, Wilson, W. David, Karim, Saadia A., Morton, Jennifer P., Neidle, Stephen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2020
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429975/
https://ncbi.nlm.nih.gov/pubmed/32832034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00317
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