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Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands

G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to...

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Detalhes bibliográficos
Main Authors: Hampel, Sonja M., Pepe, Antonella, Greulich-Bode, Karin M., Malhotra, Sanjay V., Reszka, Anthony P., Veith, Sebastian, Boukamp, Petra, Neidle, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558810/
https://ncbi.nlm.nih.gov/pubmed/23188717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081075
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