Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands

G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to...

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Main Authors: Hampel, Sonja M., Pepe, Antonella, Greulich-Bode, Karin M., Malhotra, Sanjay V., Reszka, Anthony P., Veith, Sebastian, Boukamp, Petra, Neidle, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558810/
https://ncbi.nlm.nih.gov/pubmed/23188717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.081075
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