The use of GEM models for experimental cancer therapeutics

Por Gopinathan, Aarthi, Tuveson, David A.
Publicado em 2008

GEMMs as preclinical models for testing pancreatic cancer therapies

Por Gopinathan, Aarthi, Morton, Jennifer P., Jodrell, Duncan I., Sansom, Owen J.
Publicado no Dis Model Mech (2015)

The pancreas cancer microenvironment

Por Feig, Christine, Gopinathan, Aarthi, Neesse, Albrecht, Chan, Derek S., Cook, Natalie, Tuveson, David A.
Publicado em 2012

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Por Cook, Natalie, Frese, Kristopher K., Bapiro, Tashinga E., Jacobetz, Michael A., Gopinathan, Aarthi, Miller, Jodi L., Rao, Sudhir S., Demuth, Tim, Howat, William J., Jodrell, Duncan I., Tuveson, David A.
Publicado em 2012

MRI with hyperpolarised [1-(13)C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

Por Serrao, Eva M, Kettunen, Mikko I, Rodrigues, Tiago B, Dzien, Piotr, Wright, Alan J, Gopinathan, Aarthi, Gallagher, Ferdia A, Lewis, David Y, Frese, Kristopher K, Almeida, Jaime, Howat, William J, Tuveson, David A, Brindle, Kevin M
Publicado no Gut (2016)

A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma

Por Cook, Natalie, Basu, Bristi, Smith, Donna-Michelle, Gopinathan, Aarthi, Evans, Jeffry, Steward, William P, Palmer, Daniel, Propper, David, Venugopal, Balaji, Hategan, Mirela, Anthoney, D Alan, Hampson, Lisa V, Nebozhyn, Michael, Tuveson, David, Farmer-Hall, Hayley, Turner, Helen, McLeod, Robert, Halford, Sarah, Jodrell, Duncan
Publicado no Br J Cancer (2018)

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Por DeNicola, Gina M., Karreth, Florian A., Humpton, Timothy J., Gopinathan, Aarthi, Wei, Cong, Frese, Kristopher, Mangal, Dipti, Yu, Kenneth H., Yeo, Charles J., Calhoun, Eric S., Scrimieri, Francesca, Winter, Jordan M., Hruban, Ralph H., Iacobuzio-Donahue, Christine, Kern, Scott E., Blair, Ian A., Tuveson, David A.
Publicado em 2011

mTORC2 signaling drives the development and progression of pancreatic cancer

Por Driscoll, David R, Karim, Saadia A, Sano, Makoto, Gay, David M, Jacob, Wright, Yu, Jun, Mizukami, Yusuke, Gopinathan, Aarthi, Jodrell, Duncan I, Evans, TR Jeffry, Bardeesy, Nabeel, Hall, Michael N, Quattrochi, Brian J., Klimstra, David S., Barry, Simon T, Sansom, Owen J, Lewis, Brian C, Morton, Jennifer P
Publicado no Cancer Res (2016)

CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response

Por Biasci, Daniele, Smoragiewicz, Martin, Connell, Claire M., Wang, Zhikai, Gao, Ya, Thaventhiran, James E. D., Basu, Bristi, Magiera, Lukasz, Johnson, T. Isaac, Bax, Lisa, Gopinathan, Aarthi, Isherwood, Christopher, Gallagher, Ferdia A., Pawula, Maria, Hudecova, Irena, Gale, Davina, Rosenfeld, Nitzan, Barmpounakis, Petros, Popa, Elizabeta Cristina, Brais, Rebecca, Godfrey, Edmund, Mir, Fraz, Richards, Frances M., Fearon, Douglas T., Janowitz, Tobias, Jodrell, Duncan I.
Publicado no Proc Natl Acad Sci U S A (2020)

CSF1R(+) Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

Por Candido, Juliana B., Morton, Jennifer P., Bailey, Peter, Campbell, Andrew D., Karim, Saadia A., Jamieson, Thomas, Lapienyte, Laura, Gopinathan, Aarthi, Clark, William, McGhee, Ewan J., Wang, Jun, Escorcio-Correia, Monica, Zollinger, Raphael, Roshani, Rozita, Drew, Lisa, Rishi, Loveena, Arkell, Rebecca, Evans, T.R. Jeffry, Nixon, Colin, Jodrell, Duncan I., Wilkinson, Robert W., Biankin, Andrew V., Barry, Simon T., Balkwill, Frances R., Sansom, Owen J.
Publicado no Cell Rep (2018)

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Por Olive, Kenneth P., Jacobetz, Michael A., Davidson, Christian J., Gopinathan, Aarthi, McIntyre, Dominick, Honess, Davina, Madhu, Basetti, Goldgraben, Mae A., Caldwell, Meredith E., Allard, David, Frese, Kristopher K., DeNicola, Gina, Feig, Christine, Combs, Chelsea, Winter, Stephen P., Ireland, Heather, Reichelt, Stefanie, Howat, William J., Chang, Alex, Dhara, Mousumi, Wang, Lifu, Rückert, Felix, Grützmann, Robert, Pilarsky, Christian, Izeradjene, Kamel, Hingorani, Sunil R., Huang, Pearl, Davies, Susan E., Plunkett, William, Egorin, Merrill, Hruban, Ralph H., Whitebread, Nigel, McGovern, Karen, Adams, Julian, Iacobuzio-Donahue, Christine, Griffiths, John, Tuveson, David A.
Publicado em 2009