Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease that is refractory to medical intervention. Notch pathway antagonism has been shown to prevent pancreatic preneoplasia progression in mouse models, but potential benefits in the setting of an established PDA tumor have not been establ...

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Detaylı Bibliyografya
Asıl Yazarlar: Cook, Natalie, Frese, Kristopher K., Bapiro, Tashinga E., Jacobetz, Michael A., Gopinathan, Aarthi, Miller, Jodi L., Rao, Sudhir S., Demuth, Tim, Howat, William J., Jodrell, Duncan I., Tuveson, David A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2012
Konular:
Brief Definitive Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302221/
https://ncbi.nlm.nih.gov/pubmed/22351932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111923
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