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nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

nab-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (PDA). The limited availability of patient tissue and exquisite sensitivity of xenografts to che...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Frese, Kristopher K., Neesse, Albrecht, Cook, Natalie, Bapiro, Tashinga E., Lolkema, Martijn P., Jodrell, Duncan I., Tuveson, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866937/
https://ncbi.nlm.nih.gov/pubmed/22585996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0242
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