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nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

nab-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (PDA). The limited availability of patient tissue and exquisite sensitivity of xenografts to che...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Frese, Kristopher K., Neesse, Albrecht, Cook, Natalie, Bapiro, Tashinga E., Lolkema, Martijn P., Jodrell, Duncan I., Tuveson, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866937/
https://ncbi.nlm.nih.gov/pubmed/22585996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0242
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