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nab-paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

nab-paclitaxel, an albumin-stabilized paclitaxel formulation, demonstrates clinical activity when administered in combination with gemcitabine in patients with metastatic pancreatic ductal adenocarcinoma (PDA). The limited availability of patient tissue and exquisite sensitivity of xenografts to che...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Frese, Kristopher K., Neesse, Albrecht, Cook, Natalie, Bapiro, Tashinga E., Lolkema, Martijn P., Jodrell, Duncan I., Tuveson, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866937/
https://ncbi.nlm.nih.gov/pubmed/22585996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0242
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