Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, we found that the tumors in this model were poorly perfused and p...

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Detalhes bibliográficos
Main Authors: Olive, Kenneth P., Jacobetz, Michael A., Davidson, Christian J., Gopinathan, Aarthi, McIntyre, Dominick, Honess, Davina, Madhu, Basetti, Goldgraben, Mae A., Caldwell, Meredith E., Allard, David, Frese, Kristopher K., DeNicola, Gina, Feig, Christine, Combs, Chelsea, Winter, Stephen P., Ireland, Heather, Reichelt, Stefanie, Howat, William J., Chang, Alex, Dhara, Mousumi, Wang, Lifu, Rückert, Felix, Grützmann, Robert, Pilarsky, Christian, Izeradjene, Kamel, Hingorani, Sunil R., Huang, Pearl, Davies, Susan E., Plunkett, William, Egorin, Merrill, Hruban, Ralph H., Whitebread, Nigel, McGovern, Karen, Adams, Julian, Iacobuzio-Donahue, Christine, Griffiths, John, Tuveson, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998180/
https://ncbi.nlm.nih.gov/pubmed/19460966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171362
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