Applications for ROCK kinase inhibition

Por Olson, Michael F
Publicado em 2008

Trailblazing LIM kinases take the lead in collective tumor cell invasion

Por Crighton, Diane, Olson, Michael F
Publicado em 2011

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

Por Rath, Nicola, Olson, Michael F
Publicado em 2012

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

Por Unbekandt, Mathieu, Olson, Michael F.
Publicado em 2014

Rho-associated coiled-coil containing kinases (ROCK): Structure, regulation, and functions

Por Julian, Linda, Olson, Michael F
Publicado em 2014

The Rho GTPase Effector ROCK Regulates Cyclin A, Cyclin D1, and p27(Kip1) Levels by Distinct Mechanisms

Por Croft, Daniel R., Olson, Michael F.
Publicado em 2006

Transcriptional regulation of Rho GTPase signaling

Por Croft, Daniel R, Olson, Michael F
Publicado em 2011

Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis

Por Morin, Pierre, Flors, Cristina, Olson, Michael F.
Publicado em 2009

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

Por Sahai, Erik, Olson, Michael F., Marshall, C.J.
Publicado em 2001

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity

Por Samuel, Michael S., Lourenço, Filipe C., Olson, Michael F.
Publicado em 2011

Modeling and Imaging 3-Dimensional Collective Cell Invasion

Por Scott, Rebecca W., Crighton, Diane, Olson, Michael F.
Publicado em 2011

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

Por Coleman, Mathew L., Marshall, Christopher J., Olson, Michael F.
Publicado em 2003

Reactive oxygen species and hydrogen peroxide generation in cell migration

Por Rudzka, Dominika A, Cameron, Jenifer M, Olson, Michael F
Publicado no Commun Integr Biol (2015)

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells

Por Rath, Nicola, Kalna, Gabriela, Clark, William, Olson, Michael F.
Publicado no Sci Data (2016)

Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

Por Mezna, Mokdad, Wong, Ai Ching, Ainger, Margaret, Scott, Rebecca W, Hammonds, Tim, Olson, Michael F
Publicado em 2011

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21(Waf1/Cip1) Stability

Por Densham, Ruth M., O'Neill, Eric, Munro, June, König, Ireen, Anderson, Kurt, Kolch, Walter, Olson, Michael F.
Publicado em 2009

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation

Por Brady, Suzanne C., Coleman, Mathew L., Munro, June, Feller, Stephan M., Morrice, Nicolas A., Olson, Michael F.
Publicado em 2009

Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration

Por Croft, Daniel R., Coleman, Mathew L., Li, Shuixing, Robertson, David, Sullivan, Teresa, Stewart, Colin L., Olson, Michael F.
Publicado em 2005

Elevated LIM kinase 1 in non-metastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation

Por Mardilovich, Katerina, Gabrielsen, Mads, McGarry, Lynn, Orange, Clare, Patel, Rachana, Shanks, Emma, Edwards, Joanne, Olson, Michael F
Publicado no Mol Cancer Ther (2014)

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

Por Klejnot, Marta, Gabrielsen, Mads, Cameron, Jenifer, Mleczak, Andrzej, Talapatra, Sandeep K., Kozielski, Frank, Pannifer, Andrew, Olson, Michael F.
Publicado no Acta Crystallogr D Biol Crystallogr (2013)