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Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
The Rho-associated (ROCK) serine/threonine kinases have emerged as central regulators of the actomyosin cytoskeleton, their main purpose being to promote contractile force generation. Aided by the discovery of effective inhibitors such as Y27632, their roles in cancer have been extensively explored...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463970/ https://ncbi.nlm.nih.gov/pubmed/22964758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.127 |
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