Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not known. Here, we provide evidence that ROCK1 and ROCK2 act redundantly to maintain actomyosin contractility...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kümper, Sandra, Mardakheh, Faraz K, McCarthy, Afshan, Yeo, Maggie, Stamp, Gordon W, Paul, Angela, Worboys, Jonathan, Sadok, Amine, Jørgensen, Claus, Guichard, Sabrina, Marshall, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798951/
https://ncbi.nlm.nih.gov/pubmed/26765561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12203
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